14C Urea Breath Test is used for primary diagnosis and post-treatment follow-up of H. pylori infections. The individual to be tested simply swallows 14C-urea. If H pylori presents, the enzyme urease produced by H pylori will metabolize 14C-urea to 14CO2 and ammonia. Then 14CO2 is transported in the blood to the lungs. When the patient exhales after a defined time this 14CO2 is captured in a breath collection card.
No special preparation is needed before the analysis and since the UBT is both non-invasive, the method enjoys high acceptance.
Cut-off value:
1. DPM ≤ 99, Negative
2. 99 < DPM ≤ 149, the device will perform a second test automatically, and if it is still greater than 99, it’s positive.
3. 149 < DPM ≤ 499, Positive+
4. 499 < DPM ≤ 1499, Positive ++
5. 1499 < DPM ≤ 2499, Positive +++
6. DPM > 2499, Positive ++++